Sulfatide deficiency-induced astrogliosis and myelin lipid dyshomeostasis are independent of Trem2-mediated microglial activation
Namrata Mittra, Sijia He, Hanmei Bao, Anindita Bhattacharjee, Sherry G. Dodds, Jeffrey L. Dupree, Xianlin Han
This study investigates the relationship between sulfatide deficiency, neuroinflammation, and lipid dyshomeostasis in a mouse model, showing Trem2's role in microglia-mediated neuroinflammation but not astrogliosis or myelin lipid disruption.
bioRxiv · Nov 14, 2024 · PreprintNeuroscience