Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset
Ana Caroline Costa-da-Silva, Rubina Sharma, Marit H. Aure, Daniel Martı́n, Noémi Kedei, Damilola F. Killanin, Ayesha Javaid, Francis A. Boksa, Drashty Paresh Mody, Joe Truong Nguyen, Sukirth M. Ganesan, Joshua T. Dodge, Clara H. Kim, Marie Kao-Hsieh, David Erwin Kleiner, , Jacqueline Wiesehan Mays
This study identifies exhausted-like effector CD8 T cells as key drivers of oral mucosal cGVHD by analyzing single-cell RNA sequencing data from biopsies collected at disease onset.
bioRxiv · Sep 11, 2025 · PreprintImmunology