Arterial smooth muscle cell PKD2 (TRPP1) channels control systemic blood pressure
Simon A. Bulley, Carlos Fernández‐Peña, Raquibul Hasan, Marie Dennis Leo, Padmapriya Muralidharan, Charles Mackay, Kirk W. Evanson, Luiz Moreira‐Júnior, Alejandro Mata‐Daboin, Sarah Kimberly Burris, Qian Wang, Korah P. Kuruvilla, Jonathan H. Jaggar
This study shows that PKD2 channels in arterial smooth muscle cells regulate blood pressure and that their removal lowers blood pressure and prevents hypertension-related arterial remodeling.
eLife · Nov 27, 2018Peer-reviewedNeuroscience