Author

Charles Mackay

University of Tennessee Health Science CenterORCID 0000-0002-2875-0677Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Alejandro Mata‐DaboiniD· 2 shared Jonathan H. JaggariD· 2 shared Marie Dennis LeoiD· 2 shared Carlos Fernández‐PeñaiD· 1 shared Kirk W. EvansoniD· 1 shared Korah P. KuruvillaiD· 1 shared Luiz Moreira‐JúnioriD· 1 shared Padmapriya MuralidharaniD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPhysiology

Alejandro Mata‐DaboinORCID

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2 papers

Recent·Most cited

Wnts are endothelial cell-derived PKD1/PKD2-dependent autocrine/paracrine vasodilators

Ulrich Carlos Mbiakop, Charles Mackay, Alejandro Mata‐Daboin, Roberto B. Pontes, Marie Dennis Leo, Jonathan H. Jaggar

This study identifies Wnt9b and Wnt5a as endothelial cell-derived PKD1/PKD2-dependent vasodilators that reduce blood pressure through autocrine/paracrine mechanisms.

Physiology · May 1, 2026Peer-reviewedPhysiology

Arterial smooth muscle cell PKD2 (TRPP1) channels control systemic blood pressure

Simon A. Bulley, Carlos Fernández‐Peña, Raquibul Hasan, Marie Dennis Leo, Padmapriya Muralidharan, Charles Mackay, Kirk W. Evanson, Luiz Moreira‐Júnior, Alejandro Mata‐Daboin, Sarah Kimberly Burris, Qian Wang, Korah P. Kuruvilla, Jonathan H. Jaggar

This study shows that PKD2 channels in arterial smooth muscle cells regulate blood pressure and that their removal lowers blood pressure and prevents hypertension-related arterial remodeling.

eLife · Nov 27, 2018Peer-reviewedNeuroscience