Daniil K. Lukyanov

Discovery of rare antigen-specific TCRs via replicate profiling

The paper develops a high-throughput TCR discovery assay to identify antigen-specific T cells, finding over 90 SARS-CoV-2-specific TCR clonotypes in one donor and nearly 1,000 in five donors.

Splicing-aware resolution of scRNA-Seq data

The paper introduces SANSARA, a method for splicing-aware scRNA-Seq analysis, revealing splicing heterogeneity in T cell subsets and interactions between transcription factors.

FCRLs and atypical transcriptional pattern in tumor infiltrating B cells from lung and renal cancer

The paper analyzes B cell subpopulations in lung and renal cancer, finding that FCRL4 expression and IgA/IgG ratios correlate with tumor progression and poor survival.