Irina A. Shagina

The paper demonstrates a repertoire-guided workflow to prioritize antibody candidates targeting β-amyloid and its isoAsp7 proteoform, identifying potential heavy-light chain combinations through computational and experimental methods.

The paper develops a high-throughput TCR discovery assay to identify antigen-specific T cells, finding over 90 SARS-CoV-2-specific TCR clonotypes in one donor and nearly 1,000 in five donors.

The paper investigates NK cell antigenic specificity by analyzing scRNA-Seq, single-cell cloning, and in silico modeling to show glycosylation's role in modulating KIR2DS4 interactions with peptide-MHCI complexes.

The paper develops a pipeline to identify and track antigen-specific T cell responses to cancer immunotherapy in mice using TCR repertoire analysis.