Larsen Vornholz

The paper creates a Human Cytokine Dictionary using single-cell transcriptomes of PBMCs stimulated with cytokines, revealing cell-type-specific responses and communication networks.

Pretrained on 57 million dissociated and 53 million spatial human and mouse cells, a 49.3M-parameter transformer predicts niche, region, neighborhood composition and density, and carries spatial labels onto scRNA-seq.