BioengineeringbioRxivPreprint
β-Cells as a Cell Factory for On-Demand Recombinant Protein Dosing: Harnessing the Neuroendocrine Cell Secretory Pathway for Controlled Release
Ella A. Thomson, Haixia Xu, Sooyeon Lee…·Ada S. Y. Poon
This paper develops a β-cell-based platform for on-demand recombinant protein delivery by modifying the endogenous insulin processing pathway to produce and release therapeutic peptides like GLP-1 or glucagon.
DOI 10.1101/2024.01.20.576492