ImmunologyProceedings of the National Academy of SciencesPeer-reviewed
A predisposing effect of HLA class II genes in celiac disease by skewing the naive CD4+ T-cell receptor repertoire
Ida Lindeman, Aengus Officer, Shiva Dahal‐Koirala…·Ludvig Magne Sollid
The paper shows HLA-DQ2.5 variants increase frequencies of TCR genes involved in gluten epitope recognition in CeD patients, linking HLA to disease by shaping the naive TCR repertoire.