Corey T. Watson

The paper identifies a disrupted CCR5-like immunoglobulin gene in black-footed ferrets linked to increased susceptibility to plague caused by Yersinia pestis.

The paper shows HLA-DQ2.5 variants increase frequencies of TCR genes involved in gluten epitope recognition in CeD patients, linking HLA to disease by shaping the naive TCR repertoire.

This paper constructs HUSA, a comprehensive germline resource linking allele diversity to expressed antibody repertoires by integrating long-read sequencing and AIRR-seq data.

This study identifies two classes of HCV E2 neutralizing antibodies from non-human primates immunized with a recombinant E1E2, showing similarity to human antibodies.

The paper identifies structural variants and coding polymorphisms in the human IGHC locus, revealing population-specific diversity and potential functional impacts.

The paper compares IG/TR loci across 44 mammalian species, finding correlations in gene counts, structural patterns linked to population bottlenecks, and haplotype diversity suggesting limited recombination potential.

This study shows that genetic variations in immunoglobulin light chain loci influence the diversity of expressed light chain antibodies, affecting amino acid sequences and gene usage.

The paper investigates how genetic variation and selection shape antibody repertoires across B cell development stages, finding distinct roles for genetics and selection in heavy and light chain repertoires.

The paper investigates how vaccine antigen delivery and adjuvant selection affect the priming of rare HIV broadly neutralizing antibody-precursor B cells in non-human primates, finding that specific dosing and adjuvant combinations enhance their detection in germinal centers.

The paper develops methodologies to generate and analyze immunoglobulin loci variation in rhesus macaques, revealing extensive diversity and expanding existing allele sets by 60%.

The paper introduces a method using ultra-long sequencing and bioinformatics to resolve haplotypes in the human immunoglobulin heavy chain locus, uncovering novel alleles and structural variants.

The paper evaluates long-read genome assemblies of immunoglobulin loci across 74 vertebrates, identifies assembly errors, and demonstrates methods to correct them using a new pipeline called CloseRead.

The paper identifies limitations of short-read sequencing in analyzing IGH regulatory regions and advocates for long-read tools to better understand germline variation's impact on antibody repertoires.

The paper curates high-quality human immunoglobulin germline gene reference sets to improve AIRR-seq analysis accuracy and facilitate immunoglobulin gene studies.

The paper shows that genetic variation in the immunoglobulin heavy chain locus influences the diversity and characteristics of the human antibody repertoire.

The paper characterizes the immunoglobulin lambda chain locus in diverse populations, identifying novel alleles and highlighting limitations of short-read sequencing.

This paper uses targeted long-read sequencing to accurately assemble and genotype TCR loci, discovering new alleles and improving variant detection compared to short-read methods.

ImmunoTyper-SR genotypes IGHV alleles from short read data and identifies associations between IGHV alleles and anti-type I IFN autoantibodies in COVID-19 patients.

This study identifies how V(D)J recombination in lymphoblastoid cell lines affects genetic data quality in immunoglobulin loci, impacting allele frequency and linkage disequilibrium estimates.

The paper introduces a framework combining long-read sequencing and a new tool to fully characterize haplotype diversity in the human immunoglobulin heavy chain locus, demonstrating high accuracy and scalability.

The paper improves the TIgGER algorithm to accurately identify subject-specific immunoglobulin alleles from AIRR-seq data, even when alleles differ by more than 5 SNPs from known database alleles.

The paper identifies de novo epigenetic variations in congenital disorders and shows their impact on gene expression and potential diagnostic relevance.

The paper identifies environmentally responsive co-regulated networks of DNA methylation variation in human cell types and shows their enrichment for imprinted loci.