Sex-specific associations between astrocytic reactivity and cognitive decline in unimpaired elderly
Chelsea Reichert Plaska, Tovia Jacobs, Davide Bruno, Sang Han Lee, Bruno Pietro Imbimbo, Ricardo Osorio, Andréa Lessa Benedet, Nicholas James Ashton, Henrik Zetterberg, Nunzio Pomara, the Frontotemporal Lobar Degeneration Neuroimaging Initiative
The paper finds that higher plasma GFAP levels in women are associated with worse episodic memory and lower Aβ42/40 ratio over time, suggesting sex-specific astrocytic reactivity linked to cognitive decline.
bioRxiv · Jul 1, 2026 · PreprintNeuroscience