Andréa Lessa Benedet

This study examines sex differences in plasma GFAP levels and their association with AD biomarkers and cognitive decline in older adults, finding higher GFAP in females but no consistent sex-specific effects on cognitive decline.

The paper examines the relationship between SV2A PET imaging and CSF synaptic protein levels in Alzheimer's disease patients and cognitively normal individuals, finding associations between lower synaptic density and specific protein markers.

This paper develops a multiple sampling scheme to construct stable brain metabolic networks from PET data, showing improved stability and reduced subject requirements compared to conventional methods.

The paper investigates GFAP-positive astrocyte responses to amyloid-beta and tau pathologies in humans and mouse models, finding distinct molecular signatures associated with each pathology.

The paper develops a personalized brain activity model integrating functional MRI, Aβ, and tau-PET to reveal synergistic effects of Aβ and tau on cognitive impairment and neuronal excitability in Alzheimer's disease.

This study investigates how long- and short-range white matter fiber depletion contributes to cognitive deficits in fronto-temporal dementia using diffusion MRI and voxel-based morphometry.

This paper introduces Constrained Instrumental Variable (CIV) methods to improve Mendelian randomization by handling pleiotropy, showing better performance in simulations and application to ADNI data.