Henrik Zetterberg

The paper identifies the CSF YWHAG:NPTX2 ratio as a biomarker for predicting clinical severity and phenoconversion in FTLD, showing strong correlation with disease progression and improved trial design potential.

The paper investigates the association between CSF complement proteins and early AD pathology in at-risk individuals, finding C1q and Factor H linked to tau and synaptic markers.

The paper identifies T-cell co-signalling states linked to vulnerability and resilience to cerebral Aβ pathology in Alzheimer's disease.

This study shows that the Gars{Delta}ETAQ mutation in mice causes specific peripheral nerve pathology in motor and sensory neurons, affecting multiple functions and providing a model for CMT2D research.

This study examines sex differences in plasma GFAP levels and their association with AD biomarkers and cognitive decline in older adults, finding higher GFAP in females but no consistent sex-specific effects on cognitive decline.

This study identifies imidazole propionate as a gut bacterial metabolite linked to Alzheimer's disease pathology through human and mouse experiments.

This study shows rheumatoid arthritis is linked to accelerated brain aging, evidenced by increased brain-age gap and neurostructural changes.

This study examines longitudinal changes in sleep EEG biomarkers of memory consolidation in middle-aged and older adults, finding declines in SO-sigma coupling and sleep spindle measures linked to synaptic integrity and memory decline.

This study shows GluN2A is essential for NMDAR function in human neurons, as evidenced by changes in calcium and ionic currents during maturation.

This study uses mouse models with tau mutations to show two distinct pathogenic mechanisms in tauopathies, with different progression patterns and responses to amyloid.

The paper identifies grey matter microstructural changes in Lewy body diseases using diffusion MRI metrics, finding increased tODI and FWF linked to cognitive impairment and p-tau217 levels.

The paper identifies a proteomic signature linked to vascular dysfunction and neurodegeneration in aging brains, highlighting thromboinflammation as an early pathway to tauopathy.

This study identifies 118 new genetic loci associated with Alzheimer's disease across diverse ancestries and discovers 48 novel risk loci, including those enriched in neuronal cell types.

This study compares five NfL immunoassays in plasma and CSF, finding four with excellent performance and noting assay-specific biases and correlations.

Pleiades, a whole-genome epigenetic model, detects Alzheimer's and Parkinson's disease from plasma cell-free DNA with high accuracy.

The paper examines the relationship between SV2A PET imaging and CSF synaptic protein levels in Alzheimer's disease patients and cognitively normal individuals, finding associations between lower synaptic density and specific protein markers.

This study shows that slow-wave sleep reduces CSF concentrations of beta-amyloid and tau in healthy adults, suggesting enhanced CSF turnover during sleep.

This study shows that common cell culture media cause non-physiological epileptiform activity in human iPSC-derived neurons due to high potassium concentrations, unlike cerebrospinal fluid.

The paper identifies novel APP transcripts that generate Aβ independently of β-secretase, showing their expression and presence in CSF.

The paper compares neuroimaging and plasma biomarkers in Lewy body dementia subtypes, finding differences in white matter integrity and plasma markers between dementia with Lewy bodies and Parkinson's disease dementia.

The paper examines immune changes in early Alzheimer's disease stages, finding altered T cell reactivity to β-amyloid-related antigens in preclinical AD and MCI.

CSF YWHAG:NPTX2 synapse protein ratio, from proteomics of 3,416 individuals across six cohorts, explains cognitive impairment beyond amyloid and tau and predicts decline (hazard ratio 15.4).

This study evaluates immunogen properties to improve antibody selection by analyzing structural and functional features and developing a tool for applying these insights.

The paper shows impaired glymphatic clearance is linked to poor outcomes in Parkinson's disease, with distinct effects on brain structure and iron distribution.

The paper identifies subtypes of brain structural changes in aging and links them to cognitive decline and Alzheimer's disease biomarkers using MRI data.

This paper introduces a new mouse model, NLFTaum/h, that shows ageing and amyloid-β can initiate tau pathology without MAPT mutations, revealing interactions between age, Aβ, and human tau.

This study detects neurodegenerative biomarkers in human cervical lymph nodes, showing higher concentrations than plasma and age-related changes in phospho-Tau-181.

This paper uses isotope-encoded mass spectrometry imaging and single plaque transcriptomics to track Aβ plaque maturation and its impact on synaptic function and toxicity in Alzheimer's disease.

This study uses high-dimensional proteomic analysis to identify TBI-specific plasma protein changes linked to injury patterns and pathophysiology in humans.