Rewriting nuclear epigenetic scripts in mitochondrial diseases as a strategy for heteroplasmy control
María Julia Pérez, Rocío B. Colombo, Sebastián Real, Marı́a Teresita Branham, Sergio R. Laurito, Carlos Torres Moraes, Lía Mayorga
This study shows that targeting nuclear DNA methylation can selectively reduce heteroplasmy in mitochondrial diseases by impairing high-heteroplasmy cells.
EMBO Molecular Medicine · Aug 11, 2025Peer-reviewedGenomics