G. Swarup

Comparative vitreous proteomic profiling of proliferative diabetic retinopathy and diabetic with no-retinopathy subjects implicates impaired autophagy in DR pathogenesis

The paper identifies novel proteins and pathways, including autophagy-related genes, in vitreous humour of diabetic retinopathy patients compared to controls.

Optineurin deficiency induces patchy hair loss but it is not sufficient to cause amyotrophic lateral sclerosis in mice

This study shows that optineurin deficiency in mice causes patchy hair loss but not ALS-like symptoms, suggesting other factors are needed for ALS development.

Optineurin promotes aggregation of mutant huntingtin and mutant ataxin-3, and reduces cytotoxicity of aggregates