G. Swarup

Optineurin is involved in regulating macrophage responses during mycobacterial infection

This study shows that optineurin deficiency impairs macrophage responses to mycobacterial infection by affecting autophagy and inflammatory cytokine production.

Transferrin-induced signaling through transferrin receptor and AKT kinase mediates formation of Rab8- and MICAL-L1-positive tubules involved in receptor recycling

This study shows that transferrin induces signaling through TFRC and AKT that promotes formation of RAB8- and MICAL-L1-positive tubules involved in transferrin receptor recycling.

Cold-induced loss of interaction with HSC70 triggers inflammasome activity of familial cold autoinflammatory syndrome-causing mutants of NLRP3

This study shows that cold-induced loss of NLRP3-HSC70 interaction triggers inflammasome activity in FCAS1-causing NLRP3 mutants.

Optineurin mediates delivery of membrane from transferrin receptor-positive endosomes to autophagosomes

This study shows optineurin facilitates membrane transfer from transferrin receptor-positive endosomes to autophagosomes, supporting autophagosome formation.

HSC70 regulates cold-induced caspase-1 hyperactivation by an autoinflammation-causing mutant of cytoplasmic immune receptor NLRC4

This study shows HSC70 inhibits NLRC4-H443P-induced caspase-1 activation by forming a complex, with temperature affecting their interaction and inflammation.