Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic responders
Dimitrios N. Sidiropoulos, Sarah M. Shin, Meredith Wetzel, Alexander A. Girgis, Daniel R. Bergman, Ludmila Danilova, Susheel Perikala, Daniel H. Shu, Janelle Marie Montagne, Atul M. Deshpande, James M. Leatherman, Lucie Dequiedt, Victoria Jacobs, Aleksandra Ogurtsova, Guanglan Mo, , Luciane Tsukamoto Kagohara
This study uses spatial multi-omics to identify TLS-associated immune niches in PDAC that correlate with improved survival in immunotherapy responders.
bioRxiv · Sep 22, 2024 · PreprintCancer Biology