Ashani T. Weeraratna

This study identifies MRGPRX4 as a melanoma driver that promotes invasion, therapy resistance, and an immunosuppressive tumor microenvironment.

The paper introduces an algorithm to correct mislabeling and align object positions in longitudinal 3D cell culture imaging, improving data integrity and reproducibility.

This study uses spatial multi-omics to identify TLS-associated immune niches in PDAC that correlate with improved survival in immunotherapy responders.

The paper develops a method to quantify gene expression memory and identify regulators of cell state transitions, showing that modulating PI3K and TGF-β pathways can reduce drug resistance in melanoma.

The paper shows that resistant fates in cancer cells are predetermined by intrinsic molecular differences, not microenvironmental factors, and can be influenced by drug type and dose.