Author

James M. Leatherman

Johns Hopkins UniversityORCID 0000-0002-1721-2128Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Elana Judith FertigiD· 3 shared Elizabeth M. JaffeeiD· 3 shared Luciane Tsukamoto KagoharaiD· 3 shared Won Jin HoiD· 3 shared Emma KartaliaiD· 2 shared Guanglan MoiD· 2 shared Jacob T. MitchelliD· 2 shared Meredith WetzeliD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

Elana Judith FertigORCID

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3 papers

Recent·Most cited

Cancer BiologyThe Journal of ImmunologyPeer-reviewedJun 1, 2026

Antigen-presenting cancer-associated fibroblasts in murine pancreatic tumors differentially control regulatory T cell phenotype and function via CXCL9 and CCL22

Saumya Y. Maru, Meredith Wetzel, Jacob T. Mitchell…·Elizabeth M. Jaffee

This study shows antigen-presenting cancer-associated fibroblasts (apCAFs) in murine pancreatic tumors influence regulatory T cell phenotype and function through CXCL9 and CCL22, affecting immune checkpoint blockade response.

DOI 10.1093/jimmun/vkag165

mousebulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJan 7, 2025

Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression

Samantha R. Guinn, Brayan Perez, Joseph A. Tandurella…·Jacquelyn W. Zimmerman

The paper investigates how cancer-associated fibroblasts (CAF) influence tumor cell behavior in pancreatic ductal adenocarcinoma by driving EMT and altering cell subtypes, with IL-8 playing a key modulatory role.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivPreprintSep 22, 2024

Spatial multi-omics reveal intratumoral humoral immunity niches associated with tertiary lymphoid structures in pancreatic cancer immunotherapy pathologic responders

Dimitrios N. Sidiropoulos, Sarah M. Shin, Meredith Wetzel…·Luciane Tsukamoto Kagohara

This study uses spatial multi-omics to identify TLS-associated immune niches in PDAC that correlate with improved survival in immunotherapy responders.

8 citations

humanspatial transcriptomics

𝕏 PostBluesky