BioengineeringbioRxivPreprint
CHIEF: An Attention-based Ensemble Learning Framework for Functional Protein Design
Zilong Geng, Yuze Wang, Tingting Liu…·Bing Zhang
CHIEF improves protein design by combining five models, achieving higher sequence recovery and lower perplexity, and successfully designing functional malate dehydrogenase.
DOI 10.1101/2025.03.07.641005