CHIEF: An Attention-based Ensemble Learning Framework for Functional Protein Design
Zilong Geng, Yuze Wang, Tingting Liu, Ao Tan, Shuo Wu, Xiaoling Guo, Ruogu Li, Xumin Hou, Kun Sun, Lei Wu, Qinghua Cui, Lin‐Tai Da, Zhiyuan Ma, Honglin Li, Bing Zhang
CHIEF improves protein design by combining five models, achieving higher sequence recovery and lower perplexity, and successfully designing functional malate dehydrogenase.
bioRxiv · Mar 7, 2025 · PreprintBioengineering