Lin‐Tai Da

This study shows citalopram reduces hepatocellular carcinoma by modulating C5aR1+ tumor-associated macrophages and enhancing CD8+ T cell anti-tumor immunity.

CHIEF improves protein design by combining five models, achieving higher sequence recovery and lower perplexity, and successfully designing functional malate dehydrogenase.

This study identifies GLUT1 as a target of SSRIs, showing citalopram inhibits HCC by reversing the Warburg effect through GLUT1 antagonism.

This study investigates how REST/NRSF regulates clustered protocadherin genes by forming directional base-specific interactions with NRSEs and altering enhancer-promoter interactions.

This paper identifies that immuno-positive neoantigens cluster in 3D genome regions and are enriched in active chromosomal compartments, suggesting 3D genome information can improve neoantigen prioritization.

This study uses molecular dynamics simulations to investigate how different umami ligands affect the structural dynamics of the T1R1-T1R3 taste receptor, identifying key residues and binding sites involved in ligand recognition.