The accuracy of polygenic score models for anthropometric traits and Type II Diabetes in the Native Hawaiian Population
Ying-Chu Lo, Tsz Fung Chan, Soyoung Jeon, Gertraud Maskarinec, Kekoa Taparra, Nathan J. Nakatsuka, Mingrui Yu, Chia‐Yen Chen, Kuang Lin, Lynne Ross Wilkens, Loı̈c Le Marchand, Christopher A. Haiman, Charleston W. K. Chiang
This study evaluates polygenic score models for anthropometric traits and Type II Diabetes in Native Hawaiians, finding reduced accuracy compared to European- or East Asian-ancestry populations.
medRxiv · Dec 25, 2023 · PreprintGenetic & Genomic Medicine