Mingrui Yu

Cross-linked volumetric DNA microscopy for dense molecular-network phenotyping in intact tissue

This paper introduces xVDM, a method for three-dimensional molecular phenotyping in intact tissues, achieving dense molecular networks and broader transcriptome recovery than traditional approaches.

Exome sequencing directly implicates 68 genes in inflammatory bowel disease

This study uses exome and genome sequencing to identify 68 genes directly associated with inflammatory bowel disease, providing clearer genetic insights and therapeutic targets.

Cystic fibrosis risk variants confer protection against inflammatory bowel disease

The paper identifies CFTR loss-of-function variants as protective against IBD using large-scale exome sequencing data and evaluates variant prioritization methods.

A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost-effective manner

The paper introduces BGE, a sequencing method that combines low-pass whole genome and deep whole exome data, showing high accuracy and cost-effectiveness for genetic variant discovery.

Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases

This paper introduces SuSiEx, a cross-population fine-mapping method that improves resolution and power by integrating data across ancestries, leading to more accurate identification of causal variants in complex traits and diseases.

The accuracy of polygenic score models for anthropometric traits and Type II Diabetes in the Native Hawaiian Population

This study evaluates polygenic score models for anthropometric traits and Type II Diabetes in Native Hawaiians, finding reduced accuracy compared to European- or East Asian-ancestry populations.

Analysis across Taiwan Biobank, Biobank Japan and UK Biobank identifies hundreds of novel loci for 36 quantitative traits

The paper identifies 979 novel genetic loci for 36 quantitative traits by analyzing data from the Taiwan Biobank, Biobank Japan, and UK Biobank, highlighting the value of diverse populations in GWAS.