Marjan De Mey

The paper maps orthogonality and domain-swap permissiveness in LysR-type transcriptional regulators by screening natural variants and constructing chimeras.

The paper develops and characterises a promoter library for Sulfolobus acidocaldarius, showing a 5-fold range of expression levels in the organism.

This study shows that genomic location affects gene expression in Sulfolobus acidocaldarius, with transcription influenced by neighboring genes and translation by proximity to replication origins.

The paper develops a mathematical model to predict how transcription factor and synthase expression levels affect the EsaI/EsaR quorum sensing system, validated with experimental data.

This study characterizes two quorum sensing systems and assesses their orthogonality to enable their simultaneous use in synthetic biology.

This study identifies bottlenecks in microbial production of partially acetylated chitooligosaccharides by analyzing co-expression of chitin deacetylases and a chitooligosaccharide synthase in E. coli.