This study investigates the genetic relationships between diabetes, coronary artery disease, and abdominal aortic aneurysm using GWAS data, revealing shared and distinct genetic components.

medRxiv · Dec 24, 2024 · PreprintGenetic & Genomic Medicine

Common and rare variant analyses combined with single-cell multiomics reveal cell-type-specific molecular mechanisms of COVID-19 severity

Sai Zhang, Johnathan Cooper‐Knock, Annika K K Weimer, Calum Harvey, Thomas Henry Julian, Cheng Wang, Jingjing Li, Simone Furini, Elisa Frullanti, Francesca Fava, Alessandra Renieri, Cuiping Pan, Jina Song, Paul Billing-Ross, Peng Gao, , Michael P. Snyder

This study combines common and rare variant analyses with single-cell multiomics to identify cell-type-specific genetic risk factors for severe COVID-19, revealing molecular mechanisms and potential therapeutic targets.

Cell Systems · Jun 3, 2022Peer-reviewedGenetic & Genomic Medicine

Measuring genetic variation in the multi-ethnic Million Veteran Program (MVP)

Haley Hunter-Zinck, Yunling Shi, Man Li, Bryan R. Gorman, Sun‐Gou Ji, Ning Sun, Teresa A. Webster, Andrew Liem, Paul Hsieh, Poornima Devineni, Purushotham Karnam, Lakshmi Radhakrishnan, Jeanette P. Schmidt, Themistocles L. Assimes, Jie Huang, , on behalf of the VA Million Veteran Program

The paper describes the design and performance of the MVP 1.0 custom Axiom array for genotyping a diverse cohort, achieving high-quality genetic data with substantial ancestral diversity.

bioRxiv · Jan 6, 2020 · PreprintGenetics