Jie Huang

Genetic Associations with Longevity in a Calabrian Cohort: A Genome-Wide Study

This study identifies genetic variants associated with longevity in a Calabrian cohort, finding one genome-wide significant variant and highlighting pathways related to aging.

A Cancer-Specific Antigen Drives Histone Acetylation by Stabilizing the Acetyltransferases

This study identifies MAGE-A10 as a cancer-specific protein that stabilizes KAT2A and KAT2B acetyltransferases, leading to increased histone acetylation and tumorigenesis.

PRS-GRID: A Cross and Within Ancestry Polygenic Risk Prediction Method Based on Individual Genetic Distance

PRS-GRID improves polygenic risk prediction by incorporating individual genetic distance to enhance accuracy for non-European populations.

A trans-ancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.

This study conducts a trans-ancestry GWAS using chronic ALT elevation as a proxy for NAFLD, identifies 77 significant loci, and validates 17 SNPs with histology and imaging data, revealing genetic links to metabolic and inflammatory traits.

Integration of rare large-effect expression variants improves polygenic risk prediction

This study integrates rare large-effect expression variants into polygenic risk scores, showing improved prediction of complex traits by including these variants in risk assessment.

PAGEANT: Personal Access to Genome and Analysis of Natural Traits

PAGEANT provides a framework for genetic reporting tools by analyzing genomic data to assess health risks and genetic traits, using publicly available genome datasets.

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.

Multi-ethnic type 2 diabetes (T2D) meta-analysis of 228,499 cases and 1,178,783 controls finds 318 previously unreported loci, 804 expression-colocalized genes, and 13 SNP-by-T2D vascular-outcome interactions.

Measuring genetic variation in the multi-ethnic Million Veteran Program (MVP)

The paper describes the design and performance of the MVP 1.0 custom Axiom array for genotyping a diverse cohort, achieving high-quality genetic data with substantial ancestral diversity.

High-throughput Multimodal Automated Phenotyping (MAP) with Application to PheWAS

This paper develops an automated high-throughput phenotyping method (MAP) that improves phenotype accuracy and scalability for PheWAS studies.

Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

The paper identifies 9 novel genetic loci, including low-frequency variants in TP53, associated with head circumference and intracranial volume in up to 46,000 individuals.

Genetics of fasting indices of glucose homeostasis using GWIS unravels tight relationships with inflammatory markers

The paper uses GWIS to analyze genetic correlations between HOMA-B/-IR and inflammatory markers, identifying novel loci and strong genetic links with PAI-1 and C-reactive protein.

Atrial Fibrillation Genetic Risk Differentiates Cardioembolic Stroke from other Stroke Subtypes

The paper assesses if genetic risk for atrial fibrillation explains cardioembolic stroke risk using genome-wide data from the Stroke Genetics Network.