Common and rare variant analyses combined with single-cell multiomics reveal cell-type-specific molecular mechanisms of COVID-19 severity
Sai Zhang, Johnathan Cooper‐Knock, Annika K K Weimer, Calum Harvey, Thomas Henry Julian, Cheng Wang, Jingjing Li, Simone Furini, Elisa Frullanti, Francesca Fava, Alessandra Renieri, Cuiping Pan, Jina Song, Paul Billing-Ross, Peng Gao, , Michael P. Snyder
This study combines common and rare variant analyses with single-cell multiomics to identify cell-type-specific genetic risk factors for severe COVID-19, revealing molecular mechanisms and potential therapeutic targets.
Cell Systems · Jun 3, 2022Peer-reviewedGenetic & Genomic Medicine