Autoimmune diabetes-dependent c-Maf SUMOylation licenses inflammatory bowel disease by reshaping the gut microbiota
Chao-Yuan Hsu, Yi-Wen Tsai, Shin‐Huei Fu, Yu-Wen Liu, Jia-Ling Dong, Yun‐Ju Yang, Yu-Wen Mai, Ling-Chun Tsai, C L Wu, Hsin-I Liang, Chi-Chin Sun, Chien-Tzung Chen, Shu‐Ping Wang, Shi‐Chuen Miaw, Huey‐Kang Sytwu
The paper shows that c-Maf SUMOylation affects gut inflammation by altering the microbiota and IL-21-IgA axis in autoimmune diabetes.
bioRxiv · Jun 19, 2026 · PreprintImmunology