Bcl-2 Oligomerizes Bax on the Mitochondrial Membrane Surface Preventing the Initial Stages of Apoptosis
Sophie E. Ayscough, Luke A. Clifton, Jörgen Ådén, Sebastian Köhler, Nicoló Paracini, James Doutch, Éilís C. Bragginton, Anna E. Leung, Oliver Bogojevic, Jia‐Fei Poon, Tamás Milán Nagy, Hanna Pauliina Wacklin, Gerhard Gröbner
This study shows Bcl-2 sequesters Bax into a complex on mitochondrial membranes, preventing pore formation and apoptosis initiation.
ACS Chemical Biology · Feb 18, 2026Peer-reviewedBiophysics