Author

Alexander Bontempo

Nova Southeastern UniversityORCID 0000-0001-7628-9590Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1

Frequent Co-Authors

Alireza HeidariiD· 2 shared Maria Rita Pastore· 2 shared Mark J. CayabyabiD· 2 shared Satoru ShindoiD· 2 shared Toshihisa KawaiiD· 2 shared Alexandra ChirinoiD· 1 shared Alexandra LugoiD· 1 shared Cristina Godoy· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersCell Biology

Alireza HeidariORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintMar 25, 2026

Low Transcriptional Complexity Cells Represent a Conserved, Aging-Relevant Maintenance State Overlooked by Single-Cell Transcriptomics

Alexander Bontempo, Prabhu Mathiyalagan

The paper identifies a previously unrecognized cellular state with low transcriptomic complexity in mature tissues, linked to aging and cellular maintenance.

DOI 10.64898/2026.02.16.706190

humanscRNA-seq

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Cell BiologybioRxivPreprintSep 4, 2024

Mechanosensing by Piezo1 regulates osteoclast differentiation via PP2A-Akt axis in periodontitis

Satoru Shindo, Shin Nakamura, Mohamad Rawas-Qalaji…·Toshihisa Kawai

This study shows that Piezo1 on preosteoclasts reduces osteoclast formation and bone resorption in periodontitis via the PP2A-Akt pathway.

5 citations

mouseexperimental assay

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MicrobiologyMicrobiology SpectrumPeer-reviewedAug 20, 2024

Inhibition of SARS-CoV-2 infection by Porphyromonas gingivalis and the oral microbiome

Alexander Bontempo, Alexandra Chirino, Alireza Heidari…·Mark J. Cayabyab

This study shows that Porphyromonas gingivalis and other oral bacteria can inhibit SARS-CoV-2 infection through cytotoxicity and unknown mechanisms, with individual variation in oral microbiome activity.

8 citations

humanexperimental assay

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