Cancer BiologyCancer DiscoveryPeer-reviewed
Suppression of NRF2-dependent cancer growth by a covalent allosteric molecular glue
Nilotpal Roy, Tine L Wyseure, I‐Chung Lo…·Matthew P. Patricelli
This paper introduces VVD-065, a covalent NRF2 inhibitor that enhances NRF2 degradation and sensitizes tumors to therapy, supporting a Phase I clinical trial.
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