The paper introduces an R-loop grammar to predict R-loop formation using sequence data and shows it outperforms previous methods across different DNA topologies.

2 citations

DNA methylationstatistical model

𝕏 PostBluesky

BioinformaticsGenesPeer-reviewedMar 25, 2021

Improving RNA branching predictions: advances and limitations

Svetlana Poznanović, Carson Wood, Michael Cloer, Christine Heitsch

The paper improves RNA branching predictions by developing a branch-and-bound algorithm to find optimal parameters for the linear function of multiloop energetics, showing near-optimal results for tRNA and 5S rRNA.

6 citations

statistical model

𝕏 PostBluesky

BioinformaticsJournal of Structural BiologyPeer-reviewedFeb 6, 2020

The challenge of RNA branching prediction: a parametric analysis of multiloop initiation under thermodynamic optimization

Svetlana Poznanović, Fidel Barrera-Cruz, Anna Kirkpatrick…·Christine Heitsch

The paper analyzes how changes in multiloop initiation parameters affect RNA structure prediction accuracy for tRNA and 5S rRNA sequences.

9 citations

statistical model

𝕏 PostBluesky