Retinoid-impregnated nanoparticles enable control of bone growth by site-specific modulation of endochondral ossification in mice
Masatake Matsuoka, Kenta Uchibe, Ningfeng Tang, Hongying Tian, Akiko Suzuki, Takeshi Oichi, Yu Usami, Ivan S. Alferiev, Satoru Otsuru, Joshua M. Abzug, John E. Herzenberg, Maurizio Pacifici, Motomi Enomoto‐Iwamoto, Michael Chorny, Masahiro Iwamoto
This paper demonstrates that retinoid-impregnated nanoparticles can modulate bone growth by selectively targeting growth plates in mice, leading to localized changes in tibia length and angulation.
Journal of Bone and Mineral Research · Jan 25, 2025Peer-reviewedPharmacology & Toxicology