Author

Cristian Privat

Hospital Clínico San CarlosORCID 0000-0002-8288-6508Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Approach:simulation· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alberto OcañaiD· 4 shared Andrés R. TejedoriD· 4 shared Jorge R. EspinosaiD· 4 shared Alejandro FeitoiD· 3 shared Lucía Paniagua‐Herranz· 3 shared Adiran GaraizariD· 2 shared Balázs GyőrffyiD· 2 shared Carlos Alonso‐MorenoiD· 2 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersMolecular Biology

Alberto OcañaORCID

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4 papers

Recent·Most cited

LGR5-high colorectal cancer defines a Wnt-active stem-like state with multimodal therapeutic vulnerabilities

Lucía Paniagua‐Herranz, Alejandro Feito, Cristian Privat, Luis Álvarez‐Carrión, Bernard Doger, Andrés R. Tejedor, Juan Antonio Ardua, Verónica Alonso, Cristina Nieto‐Jiménez, Carlos Alonso‐Moreno, Victor Moreno, Emiliano Calvo, Balázs Győrffy, Jorge R. Espinosa, Alberto Ocaña

The paper identifies LGR5-high colorectal cancer as a Wnt-active stem-like state with therapeutic vulnerabilities across multiple modalities.

bioRxiv · Oct 5, 2026 · PreprintMolecular Biology

Cooperative molecular interaction networks govern PARP1 inhibitor selectivity and binding affinity

Alejandro Feito, Natàlia DeMoya‐Valenzuela, Cristian Privat, Andrés R. Tejedor, Lucía Paniagua‐Herranz, Adiran Garaizar, Alberto Ocana, Jorge R. Espinosa

The paper uses atomistic simulations to identify molecular interactions governing PARP1 inhibitor selectivity and binding affinity, revealing key residues and cooperative networks that influence inhibitor specificity.

PLoS Computational Biology · May 26, 2026Peer-reviewedMolecular Biology

Condensate-Driven Transcriptional Reprogramming Defines Core Vulnerabilities in Esophageal and Gastric Cancers

Luis Álvarez‐Carrión, Andrés R. Tejedor, Juan Antonio Ardura, Verónica Alonso, Carlos Alonso‐Moreno, Rosana Collepardo‐Guevara, Irene Gutiérrez-Rojas, Cristian Privat, Victor Moreno, Emiliano Calvo, Balázs Győrffy, Jorge R. Espinosa, Alberto Ocana

The paper identifies condensate-driven transcriptional programs in esophageal and gastric cancers, showing their role in tumor viability and suggesting therapeutic targets.

bioRxiv · Feb 24, 2026 · PreprintBioinformatics

Benchmarking Free Energy Computational Methods for Revealing the Interactions Driving PARP1 Selective Inhibition

Alejandro Feito, Natàlia DeMoya‐Valenzuela, Cristian Privat, Andrés R. Tejedor, Marco DelValle-Carrillo, Sara Cembellín, Lucía Paniagua‐Herranz, Adiran Garaizar, J. Oller-Iscar, Alberto Ocana, Jorge R. Espinosa

This study benchmarks computational methods to predict PARP1 vs PARP2 inhibitor selectivity, finding FEP and PMF outperform MM/PBSA in accuracy.

bioRxiv · Dec 29, 2025 · PreprintBioinformatics