Igor Goryanin

From seven combination hypotheses to one testable interaction: a gated agentic AI QSP workflow applied to healthy ageing interventions

The paper develops a gated agentic AI QSP workflow to evaluate healthy ageing interventions, resulting in a single testable interaction and a trial design with an audit trail of discarded hypotheses.

A mechanistic, mortality-referenced biological age from routine blood tests: construction and temporal validation of IQN-BIOAGE-01

The paper constructs and validates a mechanistic biological age model, IQN-BIOAGE-01, that decomposes mortality risk into organ-specific axes and compares it to existing statistical clocks.

An AI-Assisted Workflow for Reconstruction, Extension, and Calibration of Quantitative Systems Pharmacology Models.

This paper introduces an AI-assisted framework for reconstructing, extending, and calibrating quantitative systems pharmacology models using large language models and SBML-based modeling.

Using AI-MIDD for Mechanistic Erythropoietin Modeling: A Digital-Twin Framework for Optimizing ESA Therapies

The paper develops an AI-MIDD-QSP digital-twin framework to optimize ESA therapies by integrating mechanistic models of erythropoiesis and identifying dose-sparing strategies.

Exploring the Potential of Large Language Models in Differential Abundance Analysis

This paper evaluates the use of large language models in differential abundance analysis, finding they can assist in report generation but face challenges like data inaccuracies and hallucinations.

Microwave emission from bees

This paper examines honeybee behavior using microwave radiometry and infrared measurements, finding stable internal temperatures and circadian rhythms, with potential applications in health monitoring and quantum computing.

Global sensitivity analysis for investigation of bacterial physiology in complex media with FBA-PRCC

The paper introduces FBA-PRCC for analyzing bacterial physiology in complex media, identifying new interaction modes and showing sensitivity coefficients provide additional insights beyond standard methods.

Evolutionary dynamics of microbial communities in bioelectrochemical systems.

The paper tracks microbial community changes in bioelectrochemical systems over 12 weeks, showing how certain genera like Geobacter dominate and adapt to electrode potentials.