Impairment in axonal translation and cytoplasmic viscosity during aging in sensory neurons
Maria Fransiska Emily, Laurent Guillaud, Sandra de la Fuente, Riya Agrawal, Susan Boerner, Yuto Akimoto, T Turkki, Marco Edoardo Rosti, Marco Terenzio
This study shows that aging reduces axonal translation in sensory neurons, linked to decreased mitochondrial activity and ATP levels, which can be partially reversed by increasing ATP synthesis.
bioRxiv · Jun 3, 2025 · PreprintNeuroscience