Author

Delphine Pagan

Centre National de la Recherche ScientifiqueORCID 0000-0002-8298-3682Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Agnese CristiniiD· 1 shared Amélie LusqueiD· 1 shared Anne Casanova· 1 shared Anne PradinesiD· 1 shared Camille Taha· 1 shared Célia DelahayeiD· 1 shared Elodie Borrull· 1 shared Estelle Clermont· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Agnese CristiniORCID

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1 paper

Recent·Most cited

Molecular BiologyScience AdvancesPeer-reviewedSep 23, 2026

Persistent TOP1 cleavage complexes in drug-tolerant cells drive adaptive resistance to EGFR-targeted therapies in lung cancer

Mathéa Géraud, Rémi Gence, Anne Casanova…·Olivier Sordet

The paper shows that persistent TOP1 cleavage complexes in drug-tolerant lung cancer cells drive adaptive resistance to EGFR-targeted therapies by promoting mutagenesis and reveals TDP1 loss as a targetable vulnerability.

DOI 10.1126/sciadv.aeh9099

humanexperimental assay

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