Author

Yongguo Zhang

University of Illinois ChicagoORCID 0000-0002-8299-0233Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Jun SuniD· 2 shared Yinglin XiaiD· 2 shared Di RaniD· 1 shared Shreya DebiD· 1 shared Ying HuiD· 1 shared Yu AniD· 1 shared Yueqing AniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 15 mutual co-author links

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2 shared papersCell Biology

Jun SunORCID

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2 papers

Recent·Most cited

Disrupted tRNA modification leads to intestinal mitochondrial dysfunction and microbial dysbiosis

Di Ran, Yongguo Zhang, Yueqing An, Ying Hu, Yinglin Xia, Jun Sun

This study shows that QTRT1 deficiency causes intestinal mitochondrial dysfunction and microbial dysbiosis in IBD, linking tRNA-Q modification to mucosal homeostasis.

bioRxiv · Nov 27, 2025 · PreprintCell Biology

Loss of intestinal endosome associated protein sorting nexin 27 disrupts epithelial barrier and promotes inflammation

Shreya Deb, Yongguo Zhang, Yu An, Yinglin Xia, Jun Sun

This study shows that loss of SNX27 in intestinal epithelial cells disrupts barrier function and promotes inflammation in mice, with reduced SNX27 expression observed in human IBD.

Cellular and Molecular Gastroenterology and Hepatology · Nov 20, 2025Peer-reviewedPhysiology