Jun Sun

Sex-linked Lung Estrobolome May Contribute to Pulmonary Hypertension Penetrance of Bmpr2 R899X Mutation via an ET-1high Endoregulatory Macrophage Phenotype

This study identifies a microbiome-estrogen-immune axis that contributes to sex-linked pulmonary hypertension in Bmpr2 R899X mutation carriers.

Disrupted tRNA modification leads to intestinal mitochondrial dysfunction and microbial dysbiosis

This study shows that QTRT1 deficiency causes intestinal mitochondrial dysfunction and microbial dysbiosis in IBD, linking tRNA-Q modification to mucosal homeostasis.

Loss of intestinal endosome associated protein sorting nexin 27 disrupts epithelial barrier and promotes inflammation

This study shows that loss of SNX27 in intestinal epithelial cells disrupts barrier function and promotes inflammation in mice, with reduced SNX27 expression observed in human IBD.

Compositional and Functional Profiling of the Gut Microbiome in Sarcoidosis

This study profiles the gut microbiome composition and function in sarcoidosis patients compared to healthy controls, finding significant functional differences in metabolic pathways.

Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension

This study shows that loss of endothelial c-IAP2 worsens Sch-PH by amplifying P2X7R-driven inflammation and microvascular apoptosis.

Meta-Signer: Metagenomic Signature Identifier based on Rank Aggregation of Features

Meta-Signer identifies metagenomic signatures for disease association by aggregating feature rankings from multiple machine learning models.

PopPhy-CNN: A Phylogenetic Tree Embedded Architecture for Convolution Neural Networks for Metagenomic Data

PopPhy-CNN uses a phylogenetic tree embedded architecture to predict host phenotype from metagenomic data, outperforming traditional and baseline models.