Cell Line Development for Bispecific Antibodies: Better Predictability Through Transposases
Sowmya Rajendran, Indira Kottayil, Lynn Webster, Divya Teja Vavilala, Molly Hunter, Monica Konar, Surya Karunakaran, Mário José dos Santos Pereira, Jeffrey Johnson, Jeremy Minshull, Ferenc L. Boldog
This paper shows that using the Leap-In transposon platform improves predictability in developing bispecific antibody-producing cell lines by enabling stable pools with predictable productivity and heterodimer fractions.
bioRxiv · Aug 12, 2025 · PreprintBioengineering