Generative design of sequence specific DNA binding proteins
Enisha Sehgal, Yuliya Politanska, Raktim Mitra, Paul T Kim, Nayim González-Rodríguez, Tushar Warrier, Andrew Kubaney, Akira Morishita, Riley N. Quijano, Jasper Butcher, Rohith Krishna, Robert J. Pecoraro, Brian J. Belmont, Nicole Roullier, Inna Goreshnik, , David A. Baker
This paper designs sequence-specific DNA binding proteins using deep learning, achieving a 100-fold improvement in success rates over previous methods.
bioRxiv · Apr 27, 2026 · PreprintSynthetic Biology