Tushar Warrier

This paper designs sequence-specific DNA binding proteins using deep learning, achieving a 100-fold improvement in success rates over previous methods.

The paper identifies DiSCs, regions co-bound by SETDB1 and Cohesin, which regulate genome topology and stem cell fate in mouse embryonic stem cells.

The paper identifies essential enhancers for pluripotency in mouse ES cells using a CRISPR-Cas9 screen and characterizes their target genes and regulatory networks.

This study uses scRNA-Seq and scATAC-Seq to show that human reprogramming occurs through asynchronous, diverse trajectories with distinct regulatory networks.

The paper introduces ASTAR-Seq, a method for parallel single-cell transcriptome and chromatin accessibility sequencing, and uses it to analyze mESCs, human cell lines, and erythroblast differentiation.