HSV-1 orchestrates host RAP80 ubiquitination by ICP0 and UL36USP to promote viral survival
Jie Wang, Yujing Deng, Dongyue Zhu, Yi Chi, Fan Liu, Chunfu Zheng, Dong Xing, Xiaofeng Zheng
This study identifies RAP80 as a target of HSV-1 ubiquitination enzymes ICP0 and UL36USP, showing how HSV-1 modulates host proteins at different infection stages to promote its survival.
bioRxiv · Jun 10, 2025 · PreprintMolecular Biology