Dong Xing

scDIAGRAM: Detecting Chromatin Compartments from Individual Single-Cell Hi-C Matrix without Imputation or Reference Features

scDIAGRAM detects chromatin compartments in single-cell Hi-C data without imputation or reference features, showing accuracy in simulated and real datasets.

HSV-1 orchestrates host RAP80 ubiquitination by ICP0 and UL36USP to promote viral survival

This study identifies RAP80 as a target of HSV-1 ubiquitination enzymes ICP0 and UL36USP, showing how HSV-1 modulates host proteins at different infection stages to promote its survival.

Experience-independent transformation of single-cell 3D genome structure and transcriptome during postnatal development of the mammalian brain

The paper generates transcriptome and 3D genome atlases of developing mouse brain cells, revealing structure-type-based cell identity and experience-independent developmental changes.

Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation Fetus

The paper introduces GeACT, a genomic database for human mid-gestation fetus cells, linking gene expression to chromatin states and identifying key transcription factors.