GeneticsHuman Molecular GeneticsPeer-reviewed
MSH2 knock-down shows CTG repeat stability and concomitant upstream demethylation at the DMPK locus in myotonic dystrophy type 1 human embryonic stem cells
Silvie Franck, Lise Barbé, Simon Ardui…·Karen Sermon
This study shows that MSH2 knock-down stabilizes CTG repeats and reduces upstream CpG methylation in DM1 hESCs, suggesting a link between DNA repair and epigenetic changes in DM1.
11 citations