Boosting Proteasome Activity: A Novel Mechanism of NMDAR Blockers Against Neurodegeneration
Fikret Şahin, Aslıhan Günel, Buse Türegün Atasoy, Ülkü Güler, Bekir Salih, Isunsu Kuzu, Mehmet Taşpınar, Özgür Çınar, Selda Kahveci
This study shows NMDAR antagonists like ketamine boost 20S proteasome activity, enhancing protein degradation and potentially treating neurodegenerative diseases.
bioRxiv · Aug 20, 2024 · PreprintNeuroscience