A single Ho-induced double-strand break at the MAT locus is lethal in Candida glabrata
Laetitia Maroc, Youfang Zhou Li, Stéphanie Boisnard, Cécile Fairhead
The paper shows that a single Ho-induced DSB at MAT is lethal in C. glabrata, but CRISPR-Cas9 can trigger mating-type switching without high lethality.
PLoS Genetics · Oct 15, 2020Peer-reviewedGenetics