Neural Inflammation in Thoracic Dorsal Root Ganglia Mediates Cardiopulmonary Spinal Afferent Sensitization in Chronic Heart Failure
Juan Hong, Samuel Gillman, Peter Ricci Pellegrino, Gang Zhao, Rongguo Ren, Steven J. Lisco, Irving H. Zucker, Dong Wang, Hanjun Wang
This study identifies neuroinflammation in thoracic dorsal root ganglia as a driver of cardiopulmonary afferent sensitization in chronic heart failure, showing that anti-inflammatory strategies can reduce inflammation and improve cardiac outcomes.
bioRxiv · Oct 22, 2025 · PreprintNeuroscience