Isolation of proteins on chromatin (iPOC) reveals signaling pathway-dependent alterations in the DNA-bound proteome
Huiyu Wang, Syed Azmal Ali, Jeroen Krijgsveld, Gianluca Sigismondo
The paper introduces iPOC, a method to isolate DNA-bound proteins, and applies it to study changes in the DNA-bound proteome upon perturbation of the PI3K/AKT/mTOR pathway.
Molecular & Cellular Proteomics · Jan 20, 2025Peer-reviewedMolecular Biology